“When Paul says that God gave them up to “vile affections,” he does not just mean that they are vile from “our perspective, though others might differ.” Remember that this is at the very center of God’s judgment. When men desired to think as though God were not there, God granted their wish in judgment, and gave them over to a reprobate mind (v. 28). This is how we know that wrath is occurring—God gives them up, God gives them over (vv. 26, 28). Remember that Paul is echoing the judgment themes found in Ps. 106, and here is another one. God granted their request, but He sent leanness to their souls (Ps. 106:15). God judges in wrath by saying yes” (Doug Wilson)
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